Ultimate VOLUME STABILITY
THE PUREST volume-stable bovine bone graft
cerabone® has been successfully applied in more than 1 Mio patients in regenerative dentistry and has been in use for more than 20 years in various medical applications (e.g. craniofacial surgery, oncology and hand and spine surgery).
UNIQUE
PRODUCTION PROCESS
cerabone® is produced from the femoral heads of cattle by a unique 1200°C manufacturing process utilizing heat and water only (free of chemical additives).
100% PURE
BONE MINERAL
The processing removes all organic components resulting in a bone mineral with exceptional purity.
PORES & BIOACTIVE SURFACE
The human-like bone structure of cerabone® with its three-dimensional pore-network and bioactive surface promote the adhesion and invasion of bone forming cells resulting in complete integration of the granules into newly formed bone matrix3.
SUPERIOR
HYDROPHILICITY
The interconnected pores and rough, extremly hydrophilic surface of cerabone® support the adhesion of proteins from the blood4.
DEPOT-EFFECT
.
The 100% pure natural bone mineral acts as a calcium reservoir slowly releasing calcium ions for bone remodeling5. The rough surface continuously binds and releases signaling molecules providing a long-term depot-effect.
predictable long-term CLINICAL OUTCOME
Retrospective analyses* have demonstrated long-term stability of cerabone® with cumulative implant survival rates of 98.91 – 100%6-10.
*with mean follow-ups of 12 – 65.93 months and dental implants placed in solely cerabone®-grafted sites or sites augmented with cerabone® in combination with autologous bone
100% PURE
human-like bone
BONE MINERAL
The long-term success of cerabone® is based on its excellent osteoconductive properties and exceptional purity, achieved by a unique 1200°C temperature treatment processing.
cerabone® is manufactured from the femoral heads of cattle by a uniquehigh temperature treatment processing free of chemical additives utilizing heat and water only.
During the final heating at >1200°C increasing the crystal size of the mineral phase, which prevents the dissolution of the crystals from the crystal structure thus increasing the stability of the graft and providing the basis for its long-term volume stability. oder Through this sophisticated processing a bone mineral with exceptional purity and a high degree of crystallinity is formed.
In contrast to non-sintered bovine bone grafts, no remnants of water and calcium carbonate are present (Tadic et al.).
Cellular osseous integration
Following implantation, different cell types involved in the wound healing cascade and growth factors originating from the wound area bind to the surface of the cerabone® granules. Subsequently, precursor cells differentiate into osteoblasts and start to produce new bone matrix. After a few months (6-9 months), the cerabone® particles are integrated into the newly formed bone matrix and the surface is completely covered by new mineralized bone resulting in a long-term stable bone situation.
Both the high degree of crystallinity and the phase purity provide ultimate volume stability.
Histomorphometrical analysis of human biopsies evaluating the resorption of cerabone® have found only limited evidence for material degradation such as phagocytosed particles of the biomaterial. Once implanted, cerabone® particles will only be resorbed superficially and can be found in the augmentation area after years.
Implant survival rates of
98.91 – 100%
Dental implants placed in solely cerabone®-grafted sites or sites augmented with cerabone® in combination with autologous bone have demonstrated long-term stability of the augmented sites with cumulative implant survival rates of 98.91 – 100% 12 – 65.93 months post-operative .
PRODUCT LINE
cerabone® is available as granules or block.
The cerabone® granules come in eight different volumes of small (0.5 – 1.0 mm) and large (1.0 – 2.0 mm) size.
The cerabone® block is available in a standardized size of 20 x 20 x 10 mm.
SMALL PARTICLES
Small cerabone® particles are particularly advantageous for contouring, e.g. for augmentation in the aesthetic region or to fill remaining gaps when a block grafting is performed. Small particles are also preferably used for the regeneration of smaller defects and intraosseous defects.
LARGE PARTICLES
Large cerabone® particles are favorable, if large volume defects (e.g. sinus floor elevation) are filled. In addition to the higher volume, there is more space between the large particles, which enables a better revascularization of bigger defects.
cerabone® SMALL granules
| Art.-No. | Particle Size | Content |
|---|---|---|
| 1510 | 0.5 – 1.0 mm | 1 x 0.5 ml |
| 1511 | 0.5 – 1.0 mm | 1 x 1.0 ml |
| 1512 | 0.5 – 1.0 mm | 1 x 2.0 ml |
| 1515 | 0.5 – 1.0 mm | 1 x 5.0 ml |
cerabone® LARGE granules
| Art.-No. | Particle Size | Content |
|---|---|---|
| 1520 | 1.0 – 2.0 mm | 1 x 0.5 ml |
| 1521 | 1.0 – 2.0 mm | 1 x 1.0 ml |
| 1522 | 1.0 – 2.0 mm | 1 x 2.0 ml |
| 1525 | 1.0 – 2.0 mm | 1 x 5.0 ml |
cerabone® block
| Art.-No. | Dimension | Content |
|---|---|---|
| 1720 | 20 x 20 x 10 mm | 1 x block |
PORES & BIOACTIVE SURFACE
Histomorphometrical analysis of human biopsies evaluating the resorption of cerabone® have found only limited evidence for material degradation such as phagocytosed particles of the biomaterial. Once implanted, cerabone® particles will only be resorbed superficially and can be found in the augmentation area after years. Human-like bone structure & excellent hydrophilic Based on its human-like bone structure featured by a three-dimensional pore network and rough surface, cerabone® supports blood clot formation and a fast and efficient penetration with fluids, blood and proteins as demonstrated by its excellent hydrophilic properties. Signaling molecules from the blood are bound and gradually released from the particles, thereby cerabone® provides a long-term depot effect.
The high crystallinity ensure a controlled and slow release of calcium ions to the surrounding tissue . So cerabone® also acts as a calcium reservoir important for bone remodeling. BLABLABLA hier könnten wir auch schon ein bißchen erklären was blut dann so im körper bzw mit dem granulat und dem defekt macht. dazu passt dann auch der nächste punkt:)
SUPERIOR HYDROPHILICITY
Based on its human-like bone structure featured by a three-dimensional pore network and rough surface, cerabone® supports blood clot formation and a fast and efficient penetration with fluids, blood and proteins as demonstrated by its excellent hydrophilic properties. Signaling molecules from the blood are bound and gradually released from the particles, thereby cerabone® provides a long-term depot effect.
The high crystallinity ensure a controlled and slow release of calcium ions to the surrounding tissue . So cerabone® also acts as a calcium reservoir important for bone remodeling.
VIDEO HYDROPHILIE
dIAGRAMM abgabe calcium
DEPOT-EFFECT
Histomorphometrical analysis of human biopsies evaluating the resorption of cerabone® have found only limited evidence for material degradation such as phagocytosed particles of the biomaterial. Once implanted, cerabone® particles will only be resorbed superficially and can be found in the augmentation area after years. Human-like bone structure & excellent hydrophilic Based on its human-like bone structure featured by a three-dimensional pore network and rough surface, cerabone® supports blood clot formation and a fast and efficient penetration with fluids, blood and proteins as demonstrated by its excellent hydrophilic properties. Signaling molecules from the blood are bound and gradually released from the particles, thereby cerabone® provides a long-term depot effect.
The high crystallinity ensure a controlled and slow release of calcium ions to the surrounding tissue . So cerabone® also acts as a calcium reservoir important for bone remodeling. BLABLABLA hier könnten wir auch schon ein bißchen erklären was blut dann so im körper bzw mit dem granulat und dem defekt macht. dazu passt dann auch der nächste punkt:)
predictable long-term CLINICAL OUTCOMEwei bis hierhin gescrollt hat kann auch nochmal ne Conclusion lesen!:)
SCIENCE
CLINICS
FAQs
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